About
Prof. Karen Duff is the Director of the UK Dementia Research Institute at UCL. Her research focuses on translational aspects of Alzheimer’s disease, particularly understanding and targeting the disease cascade.
Research Interests
- AD pathogenesis cascade
- Therapeutic development
- Translational research
- Disease mechanisms
Selected Publications
- Morgan, D., Diamond, D., Gottschall, P. et al. Aβ peptide vaccination prevents memory loss in an animal model of Alzheimer’s disease. Nature 408, 982–985 (2000). https://doi.org/10.1038/35050116
- Fowler, S.L., Behr, T.S., Turkes, E. et al. Tau filaments are tethered within brain extracellular vesicles in Alzheimer’s disease. Nat Neurosci 28, 40–48 (2025).https://doi.org/10.1038/s41593-024-01801-5
- Watamura, N., Foiani, M.S., Bez, S. et al. In vivo hyperphosphorylation of tau is associated with synaptic loss and behavioral abnormalities in the absence of tau seeds. Nat Neurosci 28, 293–307 (2025).https://doi.org/10.1038/s41593-024-01829-7