Talks

Keynotes

Cryo-EM structures of tau filaments and their impact on Alzheimer’s disease

The assembly of a small number of proteins into abundant amyloid filaments defines most human neurodegenerative diseases, including Alzheimer’s and Parkinson’s. In Alzheimer’s disease these proteins are amyloid-beta and tau. Based largely on the study of familial forms of disease, the formation of…

Michel Goedert

Day	2
Time	09:00-09:40

Insights from new models for tauopathy research and translation

Translational Research

AD Cascade

Human-relevant mouse and cell models for studying tau pathogenesis in AD and FTD-tau have recently been developed. Insights into pathogenic mechanisms and applications for translational research will be discussed.

Karen Duff

Day	3
Time	09:00-09:40

Anatomical units of space, time and memory

Alzheimer's Disease

Space and time are essential elements of episodic or conscious memory, the type of memory that is strongly impaired in Alzheimer’s patients. To introduce the symposium, we will go through a…

Menno Witter

Day	1
Time	14:00-14:30

Functional units of space, time and memory

Alzheimer's Disease

The hippocampal formation contains networks of neurons that encode our spatial surroundings, as well as neurons that we use to organize experience in time . Both elements are crucial for our…

Edvard Moser

Day	1
Time	14:40-15:10

Imaging the anatomical and structural units of memory

Alzheimer's Disease

Content TBA

Christian Döller

Day	1
Time	15:20-15:50

Neuron-selective vulnerability in prodromal AD

Alzheimer's Disease

The major population of principal neurons in layer II of the entorhinal cortex expresses especially high levels of the glycoprotein reelin. These neurons are prone to a very early increase in Aβ…

Asgeir Kobro-Flatmoen

Day	1
Time	16:20-16:50

The clinical presentation and diagnosis of AD

Alzheimer's Disease

AD diagnosis relies on clinical evaluation, neuropsychological testing, and biomarkers such as imaging techniques and cerebrospinal fluid analysis. Advancements in diagnostic criteria continue to…

Gøril Rolfseng Grøntvedt

Day	1
Time	18:30-19:00

The Norwegian Health Association: User engagement in research

Alzheimer's Disease

Public Health

The Norwegian Health Association has, as the national user organisation for persons with dementia and their next of kins, a targeted focus on user involvement in research. It has emerged as a…

Anne Rita Øksengård

Day	1
Time	19:10-19:40

Sequence of protein changes in AD

Protein Changes

AD Pathology

Alzheimer’s disease is histopathologically characterized by the deposition of amyloid plaques and the generation of neurofibrillary tangles that develop first in distinct places from where they…

Dietmar Thal

Day	2
Time	09:50-10:20

Certain subtypes of entorhinal neurons are particularly prone to the development of pathological tau species

Neural Models

Tau Pathology

In recent years the development of genetic tools specific to particular neuronal subtypes has started to illuminate how their remarkable diversity of neuronal subtypes play distinct roles in brain…

Cliff Kentros

Day	2
Time	10:30-11:00

Before the decline and beyond amyloid: early initiating events in Alzheimer’s disease

Neuroinflammation

Inflammasome

Early pathology

Early initiating events in Alzheimer’s disease (AD) go beyond amyloid pathology. Focusing on the entorhino-hippocampal system, it is shown that microglial activation and neuronal inflammasomes such…

Goran Šimić

Day	2
Time	11:30-12:00

Endosomal dysfunction triggers intraneuronal beta-amyloid in late-onset AD

Endosomal Function

Beta-amyloid

Late-onset Alzheimer’s disease (LOAD) is linked to aging and genetic risk factors like Bin1 and CD2AP. Studies in mouse neurons revealed that Bin1 and CD2AP loss of function disrupts endosome…

Claudia Almeida

Day	2
Time	12:10-12:40

Microglial changes in early stages of AD

Microglia

Early AD

The risk to develop sporadic Alzheimer’s disease can be linked to SNPs in innate immunity genes and emerging evidence points towards sex-specific microglial responses. Our work investigates how…

Kristine Freude

Day	2
Time	14:00-14:30

Lifestyle and Dementia Risk: Does It Apply to Alzheimer’s?

Lifestyle Factors

Dementia Risk

Research suggests that over 40% of dementia cases could be prevented or delayed by addressing 14 modifiable risk factors. Most of the supporting evidence comes from studies on all-cause dementia. In…

Geir Selbæk

Day	2
Time	14:40-15:10

The vicious circle between neuronal hyperexcitability and AD

Neuronal Hyperexcitability

AD Mechanisms

Neuronal hyperexcitability and hyperactivity are features that can be considered part of Alzheimer’s disease (AD) pathophysiology. There is a bidirectional mutual relationship between neuronal…

Heikki Tanila

Day	2
Time	16:30-17:00

Exercised Plasma to Treat Alzheimer’s Disease – The ExPlas Study

Exercise

Plasma Treatment

Clinical Trial

ExPlas is a first-in-human study examining the feasibility and potential impact of administering plasma from exercise-trained donors to individuals with early Alzheimer’s disease.

Atefe Tari

Day	2
Time	17:10-17:40

Roles of inflammation in Alzheimer’s disease and dementia

Inflammation

Dementia

Content TBA

Paul Edison

Day	2
Time	18:10-18:40

Ethologically relevant phenotyping of cognitive impairments in AD model mice

Behavioral Analysis

AD Models

Cognitive decline is the defining feature of Alzheimer’s disease (AD) and the primary endpoint in pre-clinical AD studies. I will present how our newly developed home-cage monitoring system…

Julija Krupic

Day	2
Time	18:50-19:20

Fine-tuning the NAD+-mitophagy axis in healthy brain ageing

NAD+ Metabolism

Brain Aging

NAD+ plays a fundamental role in life and health, including in brain resilience. Preclinical and clinical studies show an age-dependent reduction of NAD+ which is exacerbated in multiple…

Evandro Fang

Day	2
Time	19:30-20:00

Alzheimer’s disease non-core brain pathologies and pathomechanisms

Biomarkers

Neuroinflammation

Content TBA

Tormod Fladby

Day	3
Time	09:50-10:20

The Trønderbrain project – Next-generation translational medicine

Translational Medicine

Clinical Research

The Trønderbrain project is a collaborative research initiative established in 2003 by St. Olavs Hospital and NTNU. The primary goal is to advance translational research on neurodegenerative…

Katja Scheffler

Day	3
Time	11:00-11:30

Memory, time and space in the human brain – impact of early Alzheimer’s disease

AD Time Project

Temporal Dynamics

The hippocampal region is one of the first areas to be affected by Alzhimer’s pathology. Neural activity in this region underpins representation of our environmental context, including the…

Tora Bonnevie

Day	3
Time	11:40-12:10

Reuse

CC BY 4.0

Categories

Keynotes

Cryo-EM structures of tau filaments and their impact on Alzheimer’s disease

Insights from new models for tauopathy research and translation

Talks

Anatomical units of space, time and memory

Functional units of space, time and memory

Imaging the anatomical and structural units of memory

Neuron-selective vulnerability in prodromal AD

The clinical presentation and diagnosis of AD

The Norwegian Health Association: User engagement in research

Sequence of protein changes in AD

Certain subtypes of entorhinal neurons are particularly prone to the development of pathological tau species

Before the decline and beyond amyloid: early initiating events in Alzheimer’s disease

Endosomal dysfunction triggers intraneuronal beta-amyloid in late-onset AD

Microglial changes in early stages of AD

Lifestyle and Dementia Risk: Does It Apply to Alzheimer’s?

The vicious circle between neuronal hyperexcitability and AD

Exercised Plasma to Treat Alzheimer’s Disease – The ExPlas Study

Roles of inflammation in Alzheimer’s disease and dementia

Ethologically relevant phenotyping of cognitive impairments in AD model mice

Fine-tuning the NAD+-mitophagy axis in healthy brain ageing

Alzheimer’s disease non-core brain pathologies and pathomechanisms

The Trønderbrain project – Next-generation translational medicine

Memory, time and space in the human brain – impact of early Alzheimer’s disease

Reuse