About
Dr. Asgeir Kobro-Flatmoen is a neuroscientist at KISN at NTNU and co-leader of the K.G. Jebsen Centre for Alzheimers Disease. His research focuses on understanding the cellular mechanisms that underlie selective neuronal vulnerability in the early stages of Alzheimer’s disease.
Research Interests
- Cellular mechanisms of neurodegeneration
- Early markers of neural dysfunction
- Selective vulnerability in AD
- Therapeutic targeting strategies
Recent Research
His current work investigates the cellular and molecular mechanisms that make specific neurons particularly vulnerable in the early stages of Alzheimer’s disease. This research aims to identify potential therapeutic targets and develop strategies for early intervention.
Selected Publications
- Kobro-Flatmoen, A., Battistin, C., Nair, R.R., Bjorkli, C., Skender, B., Kentros, C., Gouras, G., Witter, M.P., 2023. Lowering levels of reelin in entorhinal cortex layer II-neurons results in lowered levels of intracellular amyloid-β. Brain Communications 5, fcad115. https://doi.org/10.1093/braincomms/fcad115
- Kobro-Flatmoen, A., Lagartos-Donate, M.J., Aman, Y., Edison, P., Witter, M.P., Fang, E.F., 2021. Re-emphasizing early Alzheimer’s disease pathology starting in select entorhinal neurons, with a special focus on mitophagy. Ageing Research Reviews 67, 101307. https://doi.org/10.1016/j.arr.2021.101307
- Kobro-Flatmoen, A., Nagelhus, A., Witter, M.P., 2016. Reelin-immunoreactive neurons in entorhinal cortex layer II selectively express intracellular amyloid in early Alzheimer’s disease. Neurobiology of Disease 93, 172–183. https://doi.org/10.1016/j.nbd.2016.05.012