About
Prof. Evandro Fang is a specialist in aging research, focusing on NAD+ metabolism and mitophagy in brain aging. His work investigates the molecular mechanisms that can be targeted to promote healthy brain aging.
Research Interests
- NAD+ metabolism
- Mitophagy regulation
- Brain aging mechanisms
- Therapeutic interventions
Selected Publications
- Fang, E.F., Hou, Y., Palikaras, K., Adriaanse, B.A., Kerr, J.S., Yang, B., Lautrup, S., Hasan-Olive, M.M., Caponio, D., Dan, X., Rocktäschel, P., Croteau, D.L., Akbari, M., Greig, N.H., Fladby, T., Nilsen, H., Cader, M.Z., Mattson, M.P., Tavernarakis, N., Bohr, V.A., 2019. Mitophagy inhibits amyloid-β and tau pathology and reverses cognitive deficits in models of Alzheimer’s disease. Nat Neurosci 22, 401–412. https://doi.org/10.1038/s41593-018-0332-9
- Kerr, J.S., Adriaanse, B.A., Greig, N.H., Mattson, M.P., Cader, M.Z., Bohr, V.A., Fang, E.F., 2017. Mitophagy and Alzheimer’s Disease: Cellular and Molecular Mechanisms. Trends in Neurosciences 40, 151–166. https://doi.org/10.1016/j.tins.2017.01.002
- Lautrup, S., Sinclair, D.A., Mattson, M.P., Fang, E.F., 2019. NAD+ in Brain Aging and Neurodegenerative Disorders. Cell Metabolism 30, 630–655. https://doi.org/10.1016/j.cmet.2019.09.001