About
Prof. Gunnar Gouras is a leading researcher in experimental dementia at Lund University. His work focuses on understanding the early pathological interactions in Alzheimer’s disease, particularly between Aβ, p-tau and ApoE.
Research Interests
- Early pathological interactions in AD
- Protein interactions in neurodegeneration
- Amyloid beta and tau pathology
- Therapeutic targeting strategies
Selected Publications
- Andersson, E., Lindblom, N., Janelidze, S., Salvadó, G., Gkanatsiou, E., Söderberg, L., Möller, C., Lannfelt, L., Ge, J., Hanrieder, J., Blennow, K., Deierborg, T., Mattsson-Carlgren, N., Zetterberg, H., Gouras, G., Hansson, O., 2025. Soluble cerebral Aβ protofibrils link Aβ plaque pathology to changes in CSF Aβ42/Aβ40 ratios, neurofilament light and tau in Alzheimer’s disease model mice. Nat Aging 5, 366–375. https://doi.org/10.1038/s43587-025-00810-8
- Gouras, G.K., Tsai, J., Naslund, J., Vincent, B., Edgar, M., Checler, F., Greenfield, J.P., Haroutunian, V., Buxbaum, J.D., Xu, H., Greengard, P., Relkin, N.R., 2000. Intraneuronal Aβ42 Accumulation in Human Brain. The American Journal of Pathology 156, 15–20. https://doi.org/10.1016/S0002-9440(10)64700-1
- Snyder, E.M., Nong, Y., Almeida, C.G., Paul, S., Moran, T., Choi, E.Y., Nairn, A.C., Salter, M.W., Lombroso, P.J., Gouras, G.K., Greengard, P., 2005. Regulation of NMDA receptor trafficking by amyloid-β. Nat Neurosci 8, 1051–1058. https://doi.org/10.1038/nn1503